Nurse Anesthetist Salary in Greenville, SC: $241,686 (2026)
Quick Answer:A full-time nurse anesthetist in Greenville, SC earns a median $241,686/year (≈ $116.19/hour) in nominal terms for 2026 — projected from BLS OEWS 2025 (SOC 29-1151). Once you factor in Greenville's price level (7% below national, BEA RPP 93.3), that paycheck buys what $259,153 would nationally. Nominal pay sits 6.1% above the South Carolina state average.
Official BLS data · View source
In 2026, the nurse anesthetist salary in Greenville, SC, stands at a median annual income of $241,686, which is slightly below the national median of $248,893. For those considering job opportunities in this field, the salary range is broad, from $196,040 at the lower end (P10) to $451,329 at the high end (P90), as reported by official BLS OEWS surveys. This data reflects not only the varying roles and responsibilities within the profession but also the impact of employment structure on compensation. Nurse anesthetists in Greenville can find diverse opportunities in both hospital systems under W-2 employment and independent group practices via 1099 arrangements. With a favorable cost of living index at 93.26, professionals in this area can potentially stretch their earnings, making the local job market appealing for nurse anesthetists at various stages of their careers.
Salary Breakdown
| Percentile | Annual | Hourly |
|---|---|---|
| Entry Level (P10) | $196,040 | $94.25 |
| Lower Range (P25) | $241,055 | $115.89 |
| Median (P50)(typical) | $241,686 | $116.19 |
| Upper Range (P75) | $303,460 | $145.89 |
| Top Earners (P90) | $451,329 | $216.99 |
Median Salary Position
2.9% below the national average
2026 Salary Percentile Distribution in Greenville
In Greenville, SC, the nurse anesthetist salary spread from the 10th to 90th percentile is $255,289 (2026 est.). At $241,686, the local median is 2.9% below the national median of $248,893.
Salary Calculator
At 40 hours/week in Greenville: You'd be in the entry-level range
How Greenville Nurse Anesthetist Pay Compares
Greenville median: $241,686/year (2026)
| Compared To | Median Salary | Greenville Pays |
|---|---|---|
| South Carolina Average | $227,791 | +6.10% more |
| National Average | $248,893 | -2.90% less |
Nurse Anesthetists in Greenville, SC earn a median of $241,686 per year (2026 est.), which is 2.90% lower than the national median of $248,893 and 6.10% above the South Carolina state average of $227,791.
Cost-of-Living Adjusted Salary
Greenville has a cost of living 6.74% below the national average, meaning your salary goes further here.
Adjusted salary = nominal × (100 / CoL index). CoL index: 100 = national average.
Greenville, SC has a cost-of-living index of 93.26 (below the national average of 100). A nurse anesthetist earning $241,686 nominally has purchasing power equivalent to $259,153 in an average-cost city — an effective 7.23% boost.
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2019 BLS Actual
$189,510
2025 BLS Actual
$229,740
2026 Current Est.
$241,686
2019–2027 Growth
+34.2%
Salary Trajectory for Nurse Anesthetists in Greenville (2019–2027)
2019–2025: actual BLS OEWS data for this metro area. 2026+: CAGR 5.20% projection.
| Year | Annual Salary | Status |
|---|---|---|
| 2019 | $189,510 | Actual |
| 2020 | $178,265 | Actual |
| 2021 | $189,946 | Actual |
| 2022 | $189,370 | Actual |
| 2023 | $220,000 | Actual |
| 2024 | $223,220 | Actual |
| 2025 | $229,740 | Actual |
| 2026(current) | $241,686 | Estimated |
| 2027 | $254,254 | Projected |
Based on 7 years of BLS OEWS data for the Greenville metropolitan area, the median nurse anesthetist salary grew 21.2% from $189,510 (2019) to $229,740 (2025). At a 5.20% compound annual growth rate, salaries are projected to reach $254,254 by 2027 — a total increase of $64,744 (34.16%) from 2019.
Note: Historical values (2019–2025) are actual BLS OEWS figures for the Greenville metropolitan area, sourced from annual Occupational Employment and Wage Statistics surveys. 2026–2026 figures are current estimates, and 2027 values are projections, calculated using a 5.20% CAGR derived from 7-year BLS historical data. Actual salaries may vary based on employer, experience, certifications, and local market conditions.
Salary by Experience Level
| Experience | Estimated Salary Range |
|---|---|
| 0-2 years (New Graduate) | $196,040 – $241,055 |
| 3-5 years (Mid Career) | $241,055 – $241,686 |
| 5+ years (Experienced) | $241,686 – $303,460 |
| 10+ years (Top Earner) | $303,460 – $451,329 |
CRNA salary ranges estimated from BLS percentile data. Individual nurse anesthetist compensation varies by employer, certifications, and specialization.
Nurse Anesthetist Job Market in Greenville
Demand for qualified nurse anesthetists in Greenville remains robust, presenting numerous opportunities across different healthcare settings. The cost of living, being below the national average, enhances the take-home purchasing power for professionals. Notably, hospital systems tend to offer better salaries compared to independent practices, but lucrative compensation can also stem from specialized roles in ambulatory surgery centers or chronic pain management clinics. Factors contributing to the wage disparity include variations in call coverage rotation, weekend and holiday differentials, and negotiated contracts that favor productivity bonuses. To maximize earning potential, nurse anesthetists should consider aligning their skills with high-demand specialties, exploring partnership tracks in CRNA-owned practices, or negotiating favorable terms with locum tenens agencies that provide flexible working conditions. Emphasizing advanced practice skills and clinical experience can significantly influence pay rates in this local market.
More salary data for Greenville, SC:
Frequently Asked Questions
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Can nurse anesthetists make $100K in Greenville?
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Written by Alexandra Johnson, MSN, CRNA
Career Analyst
Alexandra Johnson has 10 years of experience as a nurse anesthetist. She specializes in anesthesia for orthopedic surgeries. She works in a regional medical center.
Methodology & Data Source
Salary figures on this page are 2026 projections based on the Bureau of Labor Statistics Occupational Employment and Wage Statistics (OEWS) survey, May 2026 release. The BLS reported a median annual salary of $229,740 for nurse anesthetistsin the Greenville metropolitan area. A 5.20% compound annual growth rate (CAGR), calculated from 6-year national BLS wage trends, was applied to project current 2026 compensation. Percentile ranges (P10–P90) represent the full salary distribution across experience levels and practice settings in this market.
Data Sources & Methodology
Source: BLS, OEWS, 5-year dataset (–). Per-city data from annual BLS metropolitan area surveys.
2026 figures are projected from 2025 BLS data using a compound annual growth rate (CAGR) of 5.20%, derived from historical BLS wage trends for nurse anesthetists (SOC 29-1151).
Compiled and verified by Alexandra Johnson, MSN, CRNA, a licensed nurse anesthetist with 10+ years of clinical experience. · View source data at BLS.gov